Welcome to Neurostrong. Think Smarter. This is a truly unique product that is not available anywhere else. We have researched a long list of natural compounds and vitamins that, at one point or another, have been the subject of brain health claims. We have looked at whether or not those claims stand up to the science available to us. After our thorough research, we have decided to make a supplement including ingredients that have been proven by scientists to work and that complement each other for maximum benefit. Each ingredient contributes in its own different way to optimize neuronal and brain health, and it is this combination that makes Neurostrong. Think Smarter a much stronger supplement than the sum of its separate ingredients.*
In other words, our approach reflects the need to find a product that tackles the different ways by which the brain can “lose performance”. For example, there are many sources of omega-3 supplements, such as DHA, available in the market. However, there are other common causes of brain decline that are unrelated to omega-3 levels and, therefore, taking DHA supplements will not help in those cases. One such example is the amino acid homocysteine, which is a byproduct of metabolism and which can be found in excess in the brain, leading to damage in blood vessels and in neurons, and increasing the risk of stroke. That’s why our supplement, in addition to DHA, also includes vitamins B6 and B12, which are known to help reduce excess levels of homocysteine.The same argument applies to our choice of all other ingredients, they all have their own unique mechanism of action by which they can help maintain good mental health. We list them all below, with a few comments for each one about why they work and may contribute to good mental health. We also provide the links to the actual biomedical research on those ingredients. Remember, if you are interested in knowing more, or the information provided in the links is not clear enough, please write to us at email@example.com and we will love to tell you more and discuss any questions or comments that you might have.
We are also proud to say that our product satisfies current good manufacturer practices for dietary supplements. We guarantee that our product is of the finest quality and that it contains what it says on the label, no more, no less.
We are also proud to donate 10% of all profits to the *Alzheimer’s Association* so when you purchase our memory supplement you will be contributing to a good cause while taking care of your mental health.
Vitamins B6 and B12 help prevent brain volume loss
In 2008, a collaborative research between USA and UK universities reported that volunteers with greater vitamin B6 and B12 intakes had larger gray matter volume in brain cortex areas that are linked to memory and executive processes. Because loss of brain volume leads to loss of cognitive function, it reasonably follows that supplementing one’s diet with these vitamins might help cognitive function by preventing brain volume loss. To go straight to the source of these findings, visit
Note that the authors pay special attention to the fact that it is vitamin supplementation that makes the difference. When taking into account only dietary sources of these vitamins, there was no effect.
It is fair to warn, however, that this study focuses specifically on population effects rather than molecular mechanisms. In other words, if it is true that vitamins B6 and B12 are good for the brain, we need to ask how they work, what exactly it is that they do. It is not always enough to do a population study and reach meaningful conclusions without at least knowing something about the biology of the molecule that we are studying. Fortunately, those studies also exist for vitamins B6 and B12, and they also show very convincing evidence that taking them indeed contributes to good mental health. How exactly do they do that? One of the byproducts of brain metabolism is an amino acid called homocysteine. Homocysteine can accumulate in the brain, which is a bad thing for several reasons. Perhaps the two most important ones are that it can damage the cells in blood vessels, thereby increasing the risk of stroke, and it can lead to DNA damage in neurons (http://www.jneurosci.org/content/20/18/6920.long).
So too much homocysteine is responsible for vascular and neuronal damage and correlates with poorer cognitive functions. Vitamins B6 and B12 are included in our supplement because they can bring down the levels of homocysteine, and appear to increase brain volume and grey matter areas.
Ginkgo Biloba helps regulate neuronal and brain function
Ginkgo Biloba has been used for thousands of years to treat blood disorders and improve memory. In modern research, Ginkgo Biloba extract (GBE) used in medicine or as a supplement consist of a standardized product made from leaves. The positive effect of GBE on memory skills and other conditions probably stems from two of its many components, flavonoids and terpenoids. They are potent antioxidants and they have been shown in many studies to help regulate cell and tissue functions, such as blood flow, which is very important for good neuronal and brain function.
In the United States it can be marketed only as a supplement, but in Europe, particularly the health agencies from France and Germany, it is considered to be effective for the treatment of several diseases. Below are links to the actual research done to test the positive effects of GBE on a wide variety of memory and attention tests, as well as glaucoma, which is thought to be a consequence of poor blood flow:
-Tests done in healthy middle aged volunteers showed significant improvement in working memory tests within days of taking gingko biloba extracts (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166615/?tool=pubmed).
A systematic review of the effects of gingko biloba in dementia shows that it is more effective than placebo in cognitive tests (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846949/?tool=pubmed) in people who suffer from dementia.
-GBE has a desirable effect on eye blood flow in glaucoma patients. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178766/?tool=pubmed)
-A broad analysis of 29 randomized controlled group studies showed consistent evidence that chronic administration (i.e. continuously taking) GBE specifically “improves selective attention, some executive processes and long-term memory for verbal and non-verbal material”. More studies are always needed, but taken in the context of so many other studies, the evidence is encouraging.
-One final note of warning, which applies to all supplements. There is one major study from the Dutch National Institute for Public Health and the Environment that aimed to evaluate health claims on foods and herbal supplements containing GBE.
Disturbingly, these scientists revealed that, out of 29 products analyzed, 25 of them did not have the required minimum amount of GBE and the content of substances typical of GBE did not conform to what was declared on the label. Not surprisingly, taking these fraudulent supplements showed no benefits. The lesson to take home is to make sure that any food and herbal supplements or extracts that we purchase are of the appropriate quality. In that sense, we would like to point out again that our product satisfies good manufacturer practices for dietary supplements and we guarantee that our product is of the finest quality and that it contains what it says on the label, no more, no less.
DHA is absolutely required for brain development and maintenance
DHA is perhaps the most popular dietary supplement for mental health. DHA stands for docosahexaenoic acid, and is the most abundant omega-3 polyunsaturated fatty acid (PUFA) in the brain. DHA is absolutely required for the development of the human brain, as well as for its maintenance, and it is therefore assumed that appropriate regulation of DHA levels is key for mental health and cognitive functions. DHA deficiency in the brain accordingly leads to deterioration at many levels and can even cause some mental disorders. In summary, the evidence that appropriate regulation of DHA levels in the brain might be beneficial is very compelling. We are providing here the links to a couple of scientific reports describing in detail the neuroprotective roles of PUFAs in general and DHA in particular.
Grape seed extract (95% proanthocyanidins) prevents oxidative damage
We have included natural Grape seed extract in our recipe for Neurostrong. Think Smarter. It contains highly concentrated proanthocyanidins, which are a type of polyphenols with anti-oxidant properties. Anti-oxidant molecules fight oxidative damage, which occurs in every cell of the body as a by-product of normal function, and it is prominent in a variety of diseases and conditions, such as heart failure, stroke and diabetes (http://www.ncbi.nlm.nih.gov/pubmed/21196259), and the brain is not an exception. In fact, oxidative damage is an important part of the neurodegenerative process in Alzheimer’s disease (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850111/?tool=pubmed).
It is in this context then that supplementation with grape seed extracts, with their high content of the anti-oxidant proanthocyanidins, is of potential benefit, not only for mental health but also for cellular function in general. The specific evidence in favor of such benefit comes from many respectable sources. In the laboratory, using cells in culture, researchers from the Catholic University of Korea showed neuroprotective activity of grape seed extract proanthocyanidin (http://www.ncbi.nlm.nih.gov/pubmed/21810275). Furthermore, scientists from Mount Sinai School of Medicine in New York suggest a potential application of grape derived polyphenols in Huntington’s disease, a devastating neurodegenerative disease. They show the beneficial effects of grape seed extract both in vitro and in vivo (http://www.ncbi.nlm.nih.gov/pubmed/21331299). The same authors suggest that the use of polyphenolic compounds, such as those found in grape seed extracts, could indeed be of use for the treatment of other neurodegenerative conditions, such as Alzheimer’s disease and Parkinson’s disease (http://www.ncbi.nlm.nih.gov/pubmed/20653511)
Overall, it is clear that the scientific evidence available to us is consistent with the use of grape seed extracts to maintain and improve brain health, and we think that, in combination with the other ingredients, it makes Neurostrong. Think Smarter the best mental health supplement available today.
As a final note, and to provide evidence of the overall beneficial effect of grape seed extracts, this is a link to a very interesting article from scientists at the University of Colorado describing in detail their anticancer and cancer chemopreventive potential